Home » Physiology » THE RELATIONSHIP BETWEEN LEPTIN AND ANTHROPOMETRIC PARAMETERS IN TYPE 2 DIABETIC...
THE RELATIONSHIP BETWEEN LEPTIN AND ANTHROPOMETRIC PARAMETERS IN TYPE 2 DIABETIC PATIENTS
Sold By: Joe Project Store | Item Type: Project Material | Report this? | Attributes: 65 pages | 1-5 chapters | Amount: ₦3,000 | 1 order. | Marked useful: 4,283 timesINSTANT PROJECT MATERIAL DOWNLOAD
Obesity, a state of hyperleptinemia and leptin resistance, may play a role in the aeitiopathogenesis of type 2 diabetes mellitus. Leptin hormone which was originally recognized for its role as a satiety factor has now been implicated in a wide variety of multisystem biological functions, including the regulation of glucose homeostasis. However, there is paucity of information regarding leptin and its effect on the West African population. This study was therefore aimed at studying the relationship between leptin, obesity and insulin levels in type 2 diabetes mellitus. One hundred and eighty- three diabetics (183) and 96 control non-diabetics were studied. Pulse, blood pressure and anthropometric parameters of all the respondents were measured. Fasting blood sugar (FBS) was analyzed using the glucose oxidase method and lipid profile was determined using enzymatic method. Serum leptin and serum insulin were also analysed using enzyme linked immunoassay (ELISA) method. Homeostasis Model Assessment was used to determine insulin resistance. Type 2 diabetes mellitus patients and non- diabetic controls that were normotensive with no disease complications or associated chronic illness were used for the study. The mean serum leptin levels for the diabetics and non diabetics was observed to be 4.57 ± 0.17 ng/ml and 4.70 ± 0.25ng/ml respectively (p > 0.05) and the mean insulin level for the diabetic and non diabetic groups are 4.70 ± 0.25 μU/mL and 4.49 ± 0.01
μU/mL respectively (p < 0.05). A positive correlation was observed between leptin and body mass index (BMI) in both type 2 diabetic patients (r = 0.36, p < 0.05) and non-diabetics (r = 0.48, p < 0.05). A positive correlation was also found between leptin and waist circumference (WC) in both type 2 diabetic patients (r = 0.32, p < 0.05) and non-diabetics (r = 0.39, p < 0.05). Hip circumference (HC) also correlated positively with leptin in both the diabetics (r = 0.33, p < 0.05) and non-diabetics. The study also found a positive correlation between leptin and FBS in the non-diabetic group (r = 0.21, p < 0.05) but a negative correlation in the diabetic group(r = - 0.18, p < 0.05). A correlation was also found between leptin and HOMA-IR in both the diabetic (r = - 0.018, p < 0.05) and non-diabetics (r = 0.20, p < 0.05). However there was no significant relationship between leptin and insulin in both type 2 diabetic patients (r = 0.11, p > 0.05) and non-diabetics (r = - 0.06, p < 0.05). Age, BMI and WC emerged as the independent predictors of leptin in the diabetic group while BMI, WC and HC emerged as independent predictors of leptin in the non-diabetics.
Leptin is a 167-amino-acid protein transcribed from the obese (ob) gene of mice and human subjects (Zhang et al., 1997; Brennan et al., 2006). The hormone is expressed and secreted from the adipose tissue of mice and humans, and the quantity secreted is highly correlated with body fat mass and adipocyte size (Maffei et al., 1995; Considine et al., 1996). Obese people have been shown to have higher leptin levels than normalweight in people (Maffei, 1995).
Leptin hormone was initially thought to play a vital role only in the regulation of food intake, energy expenditure, and whole-body energy balance in rodents and humans (Janechova et al., 2001). Since the discovery that leptin replacement improves insulin sensitivity and diabetes in mice homozygous for mutations of the obesity gene (obgene), it is now been implicated in the pathophysiology of obesity and is shown to play a significant role in insulin resistance related to obesity (Harris et al., 1996). Leptin is also shown to play a role in blood glucose homeostasis (Heather et al., 2012). It has also been reported to normalize blood glucose and insulin levels in ob/ob mice with type 2 diabetes mellitus (Pellymounter, et al., 1995).
This material content is developed to serve as a GUIDE for students to conduct academic research
Find What You Want By Category:
DOWNLOAD THIS PROJECT MATERIAL NOW!
For advertisement, call 08168958821
Not what you were looking for? Perform a search
What's your project topic?
Comment on Facebook:
Related Project Materials
ANALYSIS OF THE STRUCTURE AND COMPONENTS OF JOSEPH RAZ’S IDEA OF NORMATIVE SYSTEMS
ABSTRACT This work demonstrates that Raz’s infusion of reason as the basis for enforcing legal demands creates a viable alternative to the previo...More »
Item Type: Project Material | 65 pages | 4,282 engagements |
AMELIORATIVE EFFECT OF SELENIUM YEAST ON SOME PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIA...
ABSTRACT Oxidative stress and lipid peroxidation are central factors in the metabolic dysfunctions and pathologies associated with diabetes. The...More »
Item Type: Project Material | 65 pages | 4,110 engagements |
EFFECT OF AQUEOUS EXTRACT OF COWPEA (Vigna unguiculata) ON VISUOSPATIAL LEARNING AND MEMORY IN ACUTE...
ABSTRACT Learning is the act of acquiring new or modifying and re inforcing existing knowledge, while Memory is relatively the permanent storage of th...More »
Item Type: Project Material | 65 pages | 4,143 engagements |
EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS
Abstract Diabetes mellitus is characterized by hyperglycemia. Caffeine has been suggested to be capable of disrupting glucose metabolism. The effec...More »
Item Type: Project Material | 65 pages | 4,870 engagements |
EFFECTS OF HYDROETHANOLIC EXTRACT OF THE SEEDS OF Sesamumindicum ON SOME REPRODUCTIVE PARAMETERS OF ...
ABSTRACT Phytoestrogens are natural estrogenic agents present in plants. Phytoestrogens are any plant compounds structurally and/or functionally...More »
Item Type: Project Material | 65 pages | 4,022 engagements |