INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE

📄 Item Type: Project Material| 📋 55 pages| 📚 1–5 chapters| Amount: ₦5,000

INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE

📄 Project Material 📋 55 pages 📚 Chapters 1–5 💾 MS-Word & PDF

Chapters 1–5  |  ₦5,000

Get Complete Project Material Now

 INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE 

ABSTRACT
Type 2 diabetes mellitus (T2DM) is a chronic progressive disease that has continued to be a
global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting
alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is
widespread in plant foods and beverages such as tea and wine.This study therefore, sought to
investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant
properties of acarbose (in vitro). Aqueous solution of acarbose and gallic acid were prepared to a
final concentration of 25μM each. Thereafter, mixtures of the samples (50% acarbose + 50%
gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid) were prepared.
The results showed that the combination of 50% acarbose and 50% gallic acid showed the
highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α-
amylase inhibitory effect.

Furthermore, all the samples caused the inhibition of Fe2+-induced
lipid peroxidation (in vitro) in rat pancreatic tissue homogenate, with the combination of 50%
acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In
addition, all the samples showed antioxidant properties (ferric reducing property, 2, 2'-azino-bis
(-3-ethylbenzthiazoline-6-sulphonate (ABTS*) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH)
radicals scavenging abilities, and Fe2+ chelating ability). Therefore, the combinations of gallic
acid with acarbose could be employed in the management of T2DM with the comparative
advantage of possible reduction of the side effects of acarbose; nevertheless the combination of
50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of
type 2 diabetes mellitus.

This Project is for You If:

  • You are writing your final year project for the first time and don't want to make costly mistakes
  • This is your exact topic, or very close to what your supervisor gave you
  • Your supervisor has rejected one or more chapters and you don't know what to fix
  • You are stuck on Chapter 3 or data analysis and nothing is making sense
  • Your deadline is close and you are still far behind
  • You can't find enough materials anywhere for your topic
  • My project supervisor is very strict and I don't want to have any problem with my project work — I need a well structured and referenced project
  • I saw my school project requirement and I am confused on where or what to do
  • Everyone in my class has submitted their project and I haven't even started yet
  • My supervisor rejected my research methodology and I don't know what to do
  • I thought my topic was simple and easy but on Chapter 2 I cannot find any material and my work is due for submission
  • I have the content somehow but my references and bibliography are all over the place and I don't know how to arrange them properly
  • I am combining school with work and I genuinely do not have the time to write everything from scratch — I just need something to work with
  • My supervisor changed the topic I wanted and approved another one — I am confused on where to start from
  • I am scared of submitting something that will be flagged for plagiarism — I need something original that I can use as a proper guide
  • I have been browsing the internet for days looking for materials on this topic and I cannot find anything useful anywhere
  • This is not my first time doing this project — I have carried it over before and I cannot afford to do it again
  • I have written some chapters already but I am stuck midway and need to see how others handled the same topic
Yes, This Is My Situation — Send Me the Complete Material

Here's everything you get with the complete project package:

Chapters 1–5 (Word & PDF)
Abstract & Table of Contents
References, Citation & Bibliography
Fully Editable Microsoft Word Format
Original, Plagiarism-Free Content
Delivery Within 24 Hours
Complete package ₦10,000₦5,000
Price may return to ₦10,000 at any time.

See Our Conversations With Students on WhatsApp

Students sharing their experience after using our service

I've Seen Enough — Get Me This Project Material

What Other Students Are Saying

↩ View More Reviews

Can't find what you're looking for?

Search thousands of project topics across every department.

Frequently Asked Questions

Yes. All project materials on iProject are original, well-researched, and crafted to be plagiarism-free. They are intended as academic guides and reference materials.
You will receive the complete project in both Microsoft Word (.docx) and PDF formats, making it easy to edit and submit.
Once payment is confirmed, the material is delivered within 24 hours to the email address supplied at checkout.
Absolutely. The Word format is fully editable, allowing you to modify the content, swap out case studies, and adapt the material to your specific research context.
All My Questions Are Answered — Download the Complete Project