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BIOCHEMICAL EFFECT OF FIBRINOGEN

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CHAPTER ONE

1.0     Introduction

1.1     Fibrinogen

1.1.1  Fibrinogen Synthesis

1.1.2  Functions of Fibrinogen

CHAPTER TWO

2.0     Types of fibrinogen disorders

2.1     Clinical manifestations

2.1.1  Hypofibrinogenemia

2.1.2  Dysfibrinogenemia

2.2     Laboratory diagnosis

2.2.1  Molecular diagnosis

2.2.2  Dysfibrinogenemia mutations

2.2.3  Prenatal diagnosis

CHAPTER THREE

3.0     Fibrinogen Replacement

3.1     Fresh Frozen Plasma

3.2     Cryoprecipitate

3.3     Fibrinogen Concentrate

3.4     Current understanding of fibrinogen replacement

3.4.1  Preclinical Data

3.4.2  Clinical Data

3.4.2.1 Trauma

3.4.2.2 Perioperative Bleeding

CHAPTER FOUR

4.0     Conclusion and Recommendation

4.1     Conclusion

4.2     Recommendation

References.


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