River pollution in the urban areas is a common problem in many parts of Nigeria. This study examines the physio-chemical and biological parameters of the river Delimi within the Jos urban area. The specific objectives were to identify the dominant activities that constitute factors of pollution, and assess the pollution levels at different activity positions and different times of the year. Eight water samples were collected at eight locations on the river stretching from the entry point of the river to the outlet point. The results of the water analyses were compared with the WHO and National /NAFDAC water quality standards for drinking and irrigation. The results show that the concentration of pH, electrical conductivity, total dissolve solid, hydrocarbon, lead iron and BOD exceed the WHO and NAFDAC standards. Cobalt, chromium, nickel, potassium, sodium and manganese values are below the contaminant level for all the eight sample points. E.coli drancuculum larvae, hydra-organisms, small fishes, small snails’ paramecium and spirogyra were significantly present in the water samples. In order to improve the quality of the water, there is need for control or prevention of pollution activities along the river course.