The antibacterial activity of three type of medicate soap on staphylococcus aureus isolated from wound infections was conducted. Fifty individual with wound infection within the age range of 9-73 years were sampled. Swabsticks were used to collect specimens from wound infection. each swabstick was streaked separately over plates of nutrient and macconkey agar and later incubated at 370c. out of the fifty (50) individuals sampled 25(50%) were mostly infected with staphylococcus aureus followed by pseudomonas acruginqu (22%) staphylococcus epidermis (10%) least by Escherichia coli b(12%) The organisms occur within the age range 9-13 years with 8 (16%) followed by 14-18 years 4(8%) next by the age range of 19-23 years 3(6%) followed by 24-28 years with 2(4%) followed 24-28 years with 2(4%) and the heart in the age range are 29-33,34-38,39-43,44-48,49-53,54-58 64-68 with 1(2%) each while there was no isolation in the age range 59-63. The study also revealed that all the staphylococcus aureus isolated were sensitive to the three medicated soap. The means of inhibition was highest in Aleppo medicated soap with 12.92 mm followed by temperate medicated soap with 11.2mm and least in carat medicated soap with 10.56 mm. Also the staphylococcus aureus isolated were also sensitive to the commercial autibiotics used as couplers the means zones of inhibition was highest in ampiclox with 12.8 mm followed by gentamycin with 12.04 mm and the heart in penicillin with 10.4 mm. there was a close relationship in the zones of inhibition between the three medicated soap and the commercial antibiotics used as coconutrels. The result showed that medicated soaps were effective against staphylococcus aureus involved in would infection in humans and are comparable to commercial antibiotics. Therefore medicated soap can be used in cleaning the skin particularly in the affected part of the skin during the time one has hurt or cut on the skin.